A "Crush" Course on Rhabdomyolysis: Risk Stratification and Clinical Management Update for the Perioperative Clinician
Author Department
Anesthesiology
Document Type
Article, Peer-reviewed
Publication Date
5-2020
Abstract
Rhabdomyolysis, the release of myoglobin and other cellular breakdown products from necrotic muscle tissue, is seen in patients with crush injuries, drug overdose, malignant hyperthermia, muscular dystrophy, and with increasing frequency in obese patients undergoing routine procedures. For the perioperative clinician, managing the resultant shock, hyperkalemia, acidosis, and myoglobinuric acute kidney injury can present a significant challenge. Prompt recognition, hydration, and correction of metabolic disturbances may reduce or eliminate the need for long-term renal replacement therapy. This article reviews the pathophysiology and discusses key issues in the perioperative diagnosis, risk stratification, and management of rhabdomyolysis.
Recommended Citation
Cote DR, Fuentes E, Elsayes AH, Ross JJ, Quraishi SA. A "crush" course on rhabdomyolysis: risk stratification and clinical management update for the perioperative clinician [published online ahead of print, 2020 May 18]. J Anesth. 2020;10.1007/s00540-020-02792-w. doi:10.1007/s00540-020-02792-w
PMID
32424487