Metrics of diabetes risk are only minimally improved by exercise training in postmenopausal breast cancer survivors
Author Department
Hematology/Oncology; Medicine
Document Type
Article, Peer-reviewed
Publication Date
11-2019
Abstract
CONTEXT:
Insulin resistance is a risk factor for breast cancer recurrence. How exercise training changes fasting and post-glucose insulin resistance in breast cancer survivors is unknown.
OBJECTIVE:
To evaluate exercise-induced changes in post-glucose ingestion insulin concentrations, insulin resistance, and their associations with cancer-relevant biomarkers in breast cancer survivors.
SETTING:
The University of Massachusetts Kinesiology Department.
PARTICIPANTS:
Fifteen postmenopausal breast cancer survivors not meeting the physical activity guidelines (150 minutes/week of exercise).
INTERVENTION:
a supervised 12-week aerobic exercise program (60 min/day, 3-4 days/week).
MAIN OUTCOME MEASURES:
Post-glucose ingestion insulin was determined by peak insulin and area under the insulin curve (iAUC) during a five-sample oral glucose tolerance test. Insulin sensitivity was estimated from the Matsuda composite insulin sensitivity index (C-ISI). Changes in fitness and body composition were determined from submaximal VO2peak and dual energy X-ray absorptiometry (DEXA).
RESULTS:
Participants averaged 156.8±16.6 minutes/week of supervised exercise. Estimated VO2peak significantly increased (+2.8±1.4 ml/kg/min, p<0.05) and body weight significantly decreased (-1.1±0.8 kg, p<0.05) following the intervention. There were no differences in fasting insulin, iAUC, C-ISI or peak insulin following the intervention. Insulin was only significantly lower 120 minutes following glucose consumption (68.8 ± 34.5 vs. 56.2 ± 31.9 uU/ml, p<0.05), and there was a significant interaction with past/present aromatase inhibitor (AI) use for peak insulin (-11.99 (non-AI) vs +13.91 (AI) uU/mL) and iAUC (-24.03 (non-AI) vs +32.73 (AI) uU/mL).
CONCLUSIONS:
Exercise training had limited overall benefits on insulin concentrations following glucose ingestion in breast cancer survivors but was strongly influenced by AI use.
Recommended Citation
Viskochil R, Blankenship JM, Makari-Judson G, Staudenmayer J, Freedson PS, Hankinson SE, Braun B. Metrics of diabetes risk are only minimally improved by exercise training in postmenopausal breast cancer survivors. J Clin Endocrinol Metab. 2019 Nov 20.
PMID
31745553