Molecular mechanisms in non-hodgkin lymphoma
Author Department
Pathology
Document Type
Book Chapter
Publication Date
1-2016
Abstract
Hematologic malignancies are a heterogeneous group of disorders that include neoplasms derived from cells of myeloid and lymphoid lineages. These malignancies can be categorized in many ways, but the most commonly used classification today is the World Health Organization’s Classification of Tumours of Haematopoietic and Lymphoid Tissues (WHO classification). This chapter will focus on the underlying pathogenesis of lymphoproliferative disorders with some reference on how that information can be used for diagnostic and prognostic purposes. Because an in-depth discussion of the pathogenesis of lymphoproliferative disorders is enough to fill several textbooks, a select group of non-Hodgkin lymphomas will be reviewed with particular attention to how the pathogenetic mechanisms can be used to classify, diagnose, and in some cases serve as a potential therapeutic targets. Finally, there will be a brief discussion of molecular profiling and microRNAs, two areas in which our understanding of lymphomagenesis stands to grow a great deal in the coming years.
Recommended Citation
Hunt J, Fedoriw Y, Rezuke WN: Molecular mechanisms in non-hodgkin lymphoma. In Coleman WB, Tsongalis GJ (eds): The Molecular Basis of Human Cancer. New York, NY: Springer 2016.