Pregnancy offers new insights into mechanisms of breast cancer risk and resistance

Author Department

PVLSI; Medicine; Pathology

Document Type

Article, Peer-reviewed

Publication Date

9-2013

Abstract

Pregnancy induces long-lasting changes in gene expression that are associated with a reduction in breast cancer risk. Although several mechanisms have been proposed to mediate the reduction in breast cancer risk among parous women, recent studies focus attention on progenitor cells as major targets. The results suggest new biomarkers that may improve risk prediction and provide endpoints for assessment of clinical responses to prophylactic therapies.

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