Prostaglandin inhibitors in the treatment of single-system Langerhans cell histiocytosis: Pharmacologic rationale and report of two cases

Author Department

Pediatrics; Radiology

Document Type

Article, Peer-reviewed

Publication Date

10-1-2008

Abstract

Therapeutic trials have confirmed the efficacy of a number of approaches to the treatment of single-system Langerhans cell histiocytosis (LCH). Not so well studied, but with some pharmacologic rationale and anecdotal reports of clinical success, are prostaglandin inhibitors. We present here a review of the possible mechanism of action of prostaglandin inhibitors in LCH and 2 cases of single-organ, single-site LCH treated with only prostaglandin inhibitors, both with sustained favorable clinical outcomes.

Publication ISSN

0884-8734

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