Effects of Supersaturated Oxygen Therapy on Infarct Size and Microvascular Obstruction Following Myocardial Infarction: A Systematic Review and Meta-Analysis

Author Department

Cardiology; Medicine

Document Type

Article, Peer-reviewed

Publication Date

11-2025

Abstract

Background: Supersaturated oxygen (SSO₂) therapy is an emerging intervention to minimize myocardial damage and improve outcomes in patients with ST-segment elevation myocardial infarction (STEMI). This meta-analysis evaluated the efficacy of SSO₂ therapy to reduce infarct size and microvascular obstruction (MVO).

Methods: PubMed, Embase, and Cochrane databases were systematically searched for studies comparing percutaneous coronary intervention (PCI) plus SSO2 to PCI alone for STEMI. Outcomes of interest included infarct size, MVO, and subsequent major adverse cardiovascular events (MACE), all-cause mortality, re-infarction, and target vessel revascularization (TVR). Mean differences (MD) with 95% confidence intervals (CIs) were calculated using random-effects models.

Results: Six studies (n=1660) were included with 548 patients (33%) receiving SSO₂ therapy. Pooled analysis showed that PCI plus SSO₂ significantly reduced infarct size (MD -4.31; 95% CI -6.70 to -1.92; p< 0.01) and MVO (SMD -0.72; 95% CI -1.11 to -0.34; p< 0.01) compared with PCI alone. MACE, all-cause mortality, re-infarction, and TVR were comparable between the groups.

Conclusion: SSO₂ therapy significantly reduced infarct size and MVO in patients undergoing PCI for STEMI.

Keywords: Acute myocardial infarction; Meta-analysis; Percutaneous coronary intervention; Supersaturated oxygen therapy.

PMID

41297689

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