In-Hospital Outcomes and Readmissions Following Transcatheter Mitral Valve Interventions in Octogenarians and Nonagenarians
Author Department
Cardiology; Medicine
Document Type
Article, Peer-reviewed
Publication Date
9-2025
Abstract
Objective: To compare in-hospital safety outcomes and readmissions following transcatheter mitral valve (MV) repair and replacement between octogenarians (80-89 years of age) and nonagenarians (≥90 years of age) vs younger patients (≤79 years of age).
Methods: We queried the Nationwide Readmissions Database (2016-2021) to identify patients 18 years of age and older who had been hospitalized for transcatheter MV repair or replacement. The primary outcome was in-hospital all-cause mortality. Secondary outcomes included procedural complications, length of stay, total costs, and readmissions. In-hospital outcomes were compared using logistic regression model. Readmissions were compared using a Cox proportional hazards regression model.
Results: Among 60,809 patients hospitalized for transcatheter MV interventions (54,025 repairs and 6784 replacements), 22,951 (37.7%) were octogenarians, 3955 (6.5%) were nonagenarians, and 33,903 (55.8%) were ≤79 years of age. From 2016 through 2021, the volume of transcatheter MV repair and replacement increased in all age groups (all Ptrend< .001). After adjustment for demographic and clinical factors, octogenarians and nonagenarians had similar odds of in-hospital all-cause mortality with repair (adjusted odds ratio [aOR], 1.32; 95% CI, 0.98 to 1.72 for octogenarians; aOR, 1.27; 95% CI, 0.87 to 1.85 for nonagenarians) and replacement (aOR, 1.34; 95% CI, 0.93 to 1.93 for octogenarians; aOR, 2.19; 95% CI, 0.96 to 4.96 for nonagenarians) compared with younger patients. Key procedural complications, length of stay, total costs, and 180-day all-cause and heart failure readmissions were also similar between octogenarians and nonagenarians vs younger patients.
Conclusion: Octogenarians and nonagenarians undergoing transcatheter MV interventions have similar in-hospital safety outcomes and readmissions compared with clinically similar younger patients.
Recommended Citation
Ismayl M, Ahmed H, Goldsweig AM, Eleid MF, Rihal CS, Guerrero M. In-Hospital Outcomes and Readmissions Following Transcatheter Mitral Valve Interventions in Octogenarians and Nonagenarians. Mayo Clin Proc. 2025 Oct 17:S0025-6196(25)00283-6. doi: 10.1016/j.mayocp.2025.04.032. Epub ahead of print.
PMID
41108308