Feasibility of volume targeted- positive pressure ventilation for preterm infants requiring invasive ventilation in the delivery room

Author Department

Pediatrics; Healthcare Quality

Document Type

Article, Peer-reviewed

Publication Date

3-2025

Abstract

Background: Positive pressure ventilation (PPV) with high variability in delivered tidal volume (TV) may cause volutrauma. We aimed to assess feasibility of providing Volume Targeted-Positive Pressure Ventilation (VT-PPV) to preterm infants receiving invasive mechanical ventilation via endotracheal tube in the delivery room (DR).

Design/methods: TV measurements were available from a respiratory function monitor (RFM) to adjust peak inspiratory pressures to target TV of 4-6 ml/kg for participants in the intervention cohort (VT-PPV). This data was compared with a historic cohort (HC), where providers were blinded from RFM measurements.

Results: With VT-PPV, goal TV (4-6 ml/kg) was provided 40.1% of times (vs. HC:23.6%, p = 0.002); low TV (<4 ml/kg) was provided 8.6% of times (vs. HC:28.1%, p ≤ 0.001). There was no difference in higher TV provided in the two cohorts.

Conclusion: Providing VT-PPV in intubated preterm infants may be feasible in DR and may result in increased number of breaths in target range.

PMID

40148582

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