Adult Vitamin B12 Deficiency-Associated Pseudo-Thrombotic Microangiopathy: A Systematic Review of Case Reports
Author Department
Hospital Medicine; Medicine
Document Type
Article, Peer-reviewed
Publication Date
3-2024
Abstract
Cobalamin-deficient thrombotic microangiopathy or vitamin B12 deficiency presenting as pseudo-thrombotic microangiopathy is a rare disorder that can be misdiagnosed as thrombotic thrombocytopenic purpura. Patients with this condition are at risk of receiving unnecessary plasmapheresis with a potential delay in appropriate therapy with vitamin B12 supplementation. There are no established diagnostic criteria for this condition in clinical practice. We performed a systematic review of case reports published between January 2018 and January 2023 to analyze the clinical characteristics, risk factors, and patterns of laboratory markers to improve the diagnostic criteria for this condition.
Keywords: acquired ttp; cobalamin deficiency; plasmic score; pseudo-tma; pseudo-ttp; vitamin b12 deficiency anemia; vitamin b12 deficiency symptoms.
Recommended Citation
Ganipisetti VM, Maringanti BS, Lingas EC, Naha K. Adult Vitamin B12 Deficiency-Associated Pseudo-Thrombotic Microangiopathy: A Systematic Review of Case Reports. Cureus. 2024 Mar 8;16(3):e55784. doi: 10.7759/cureus.55784.
PMID
38586727