Does Gender Affect the Outcomes of Myocardial Revascularization for Left-Main Coronary Artery Disease?
Author Department
Internal Medicine; Medicine; Cardiology
Document Type
Article, Peer-reviewed
Publication Date
2-2024
Abstract
Currently, gender is not considered in the choice of the revascularization strategy for patients with unprotected left main coronary artery (ULMCA) disease. This study analyzed the effect of gender on the outcomes of percutaneous coronary intervention (PCI) vs coronary artery bypass grafting (CABG) in patients with ULMCA disease. Females who had PCI (n = 328) were compared with females who had CABG (n = 132) and PCI in males (n = 894) was compared with CABG (n = 784). Females with CABG had higher overall hospital mortality and major adverse cardiovascular events (MACE) than females with PCI. Male patients with CABG had higher MACE; however, mortality did not differ between males with CABG vs PCI. In female patients, follow-up mortality was significantly higher in CABG patients, and target lesion revascularization was higher in patients with PCI. Male patients had no difference in mortality and MACE between groups; however, MI was higher with CABG, and congestive heart failure was higher with PCI. In conclusion, women with ULMCA disease treated with PCI could have better survival with lower MACE compared with CABG. These differences were not evident in males treated with either CABG or PCI. PCI could be the preferred revascularization strategy in women with ULMCA disease.
Keywords: coronary artery bypass grafting; gender risk stratification; left main disease; percutaneous coronary intervention.
Recommended Citation
Daoulah A, Elsheikh-Mohamed NE, Yousif N, Hersi AS, Alharbi AW, Almahmeed W, Alshehri M, Alzahrani B, Elfarnawany A, Alasmari A, Abuelatta R, Al Garni T, Ghani MA, Amin H, Hashmani S, Al Nasser FOM, Hiremath N, Arafat AA, Elmahrouk Y, Kazim HM, Refaat W, Selim E, Jamjoom A, El-Sayed O, Dahdouh Z, Aithal J, Ibrahim AM, Elganady A, Qutub MA, Alama MN, Abohasan A, Hassan T, Balghith M, Hussien AF, Abdulhabeeb IAM, Ahmad O, Ramadan M, Alqahtani AH, Qenawi W, Shawky A, Ghonim AA, Elmahrouk A, Naser MJ, Abozenah M, Shawky AM, Alqahtani AM, Ahmed RA, Abdelaziz AF, Alhamid S, Lotfi A. Does Gender Affect the Outcomes of Myocardial Revascularization for Left-Main Coronary Artery Disease? Angiology. 2024 Feb;75(2):182-189. doi: 10.1177/00033197231162481. Epub 2023 Mar 11.
PMID
36905204