Antithrombotic Therapy with Transcatheter Aortic Valve Replacement
Author Department
Cardiology; Medicine
Document Type
Article, Peer-reviewed
Publication Date
7-2023
Abstract
Aortic valve replacement is a necessary management strategy for patients with severe aortic stenosis. The use of transaortic valve replacement (TAVR) has increased significantly over the last decade and now exceeds traditional surgical aortic valve replacement. Since the valve systems used in TAVR consist of bioprosthetic valve tissue encased in a metal stent frame, antithrombotic therapy recommendations cannot be extrapolated from prior data with differently constructed surgical bioprosthetic or mechanical valves. Data on the use of antithrombotic therapy with TAVR are a rapidly developing area of medicine. Choice of agents depends on several patient factors. Patients undergoing TAVR also have a relatively high incidence of subclinical valve thrombosis. The clinical impact of this phenomenon, and the implications for antithrombotic therapy, continue to evolve. It is critical for clinicians who treat patients undergoing TAVR to have a firm understanding of practice guidelines, the evolving evidence, and its implications for the use of antithrombotic therapy in these patients.
Keywords: anticoagulant; antiplatelet; antithrombotic; thrombosis; transcatheter aortic valve.
Recommended Citation
Dobesh PP, Goldsweig AM. Antithrombotic Therapy with Transcatheter Aortic Valve Replacement. Pharmacotherapy. 2023 Jul 19. doi: 10.1002/phar.2847. Epub ahead of print.
PMID
37464970