Bullous Variant of Sweet's Syndrome as a Consequence of Radioiodine Contrast Exposure

Author Department

Internal Medicine; Medicine; Pathology

Document Type

Article, Peer-reviewed

Publication Date



Bullous variant of Sweet's syndrome (SS) is a rare form of SS, which clinically presents as bullous hemorrhagic rash and demonstrates dermal neutrophilic infiltrates with segregation of dermo-epidermal junction histopathologically. We present a case of a 73-year-old patient, who initially developed a hypersensitivity reaction on exposure to a radiocontrast agent and subsequently developed blistering rashes, which were established to be from bullous SS after exclusion of other possible diagnoses. Contrast media are utilized commonly in the current era of medicine and SS is rarely identified as an adverse event from it. Bullous variant particularly presents aggressively, which when recognized early responds to steroid use with clinical recovery.