Oxcarbazepine Therapy for Complete Central Diabetes Insipidus
Oxcarbazepine and carbamazepine cause hyponatremia by unknown mechanisms. We describe a patient with complete central diabetes insipidus and seizures who developed worsening hyponatremia when her dose of oxcarbazepine was increased. The patient maintained a normal serum sodium level and has had appropriately concentrated urine for 5 years on just oxcarbazepine, despite undetectable antidiuretic hormone (ADH) levels. This suggests that oxcarbazepine (or one of its metabolites) may stimulate collecting tubule V2 receptor-G protein complex independent of ADH, resulting in increased renal tubular water reabsorption. Oxcarbazepine may be useful as an alternative therapy for patients with central diabetes insipidus.
Abdallah B, Hodgins S, Landry D, O'shea M, Braden G. Oxcarbazepine Therapy for Complete Central Diabetes Insipidus. Case Rep Nephrol Dial. 2018 Jan 31;8(1):20-24.