Oxcarbazepine Therapy for Complete Central Diabetes Insipidus

Authors

Basmah Abdallah MD, Baystate HealthFollow
Spencer Hodgins MD, Baystate HealthFollow
Daniel Landry MD, Baystate HealthFollow
Michael O'Shea M.D., Baystate HealthFollow
Gregory Braden M.D., Baystate HealthFollow

Author Department

Medicine

Document Type

Article, Peer-reviewed

Publication Date

1-2018

Abstract

Oxcarbazepine and carbamazepine cause hyponatremia by unknown mechanisms. We describe a patient with complete central diabetes insipidus and seizures who developed worsening hyponatremia when her dose of oxcarbazepine was increased. The patient maintained a normal serum sodium level and has had appropriately concentrated urine for 5 years on just oxcarbazepine, despite undetectable antidiuretic hormone (ADH) levels. This suggests that oxcarbazepine (or one of its metabolites) may stimulate collecting tubule V2 receptor-G protein complex independent of ADH, resulting in increased renal tubular water reabsorption. Oxcarbazepine may be useful as an alternative therapy for patients with central diabetes insipidus.

Recommended Citation

Abdallah B, Hodgins S, Landry D, O'shea M, Braden G. Oxcarbazepine Therapy for Complete Central Diabetes Insipidus. Case Rep Nephrol Dial. 2018 Jan 31;8(1):20-24.

PMID

29594147