Title

Frequency of Post Treatment Control Varies by ART Restart and Viral Load Criteria

Author Department

Infectious Diseases; Medicine

Document Type

Article, Peer-reviewed

Publication Date

6-2021

Abstract

Clinical trials including an analytical treatment interruption (ATI) are vital for evaluating the efficacy of novel strategies for HIV remissions. We briefly describe an interactive tool for predicting viral rebound timing in ATI trials and the impact of posttreatment controller (PTC) definitions on PTC frequency estimates. A 4-week viral load threshold of 1000 cps/ml provides both high specificity and sensitivity for PTC detection. PTC frequency varies greatly based on the definition of a PTC.

PMID

34127579

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