Frequency of Post Treatment Control Varies by ART Restart and Viral Load Criteria
Author Department
Infectious Diseases; Medicine
Document Type
Article, Peer-reviewed
Publication Date
6-2021
Abstract
Clinical trials including an analytical treatment interruption (ATI) are vital for evaluating the efficacy of novel strategies for HIV remissions. We briefly describe an interactive tool for predicting viral rebound timing in ATI trials and the impact of posttreatment controller (PTC) definitions on PTC frequency estimates. A 4-week viral load threshold of 1000 cps/ml provides both high specificity and sensitivity for PTC detection. PTC frequency varies greatly based on the definition of a PTC.
Recommended Citation
Fajnzylber J, Sharaf R, Hutchinson JN, Aga E, Bosch RJ, Hartogensis W, Jacobson JM, Connick E, Volberding P, Skiest DJ, Margolis D, Sneller MC, Little SJ, Gulick RM, Mellors JW, Gandhi RT, Schooley RT, Henry K, Tebas P, Deeks S, Chun TW, Collier AC, Hecht FM, Li JZ; CHAMP study team. Frequency of Post Treatment Control Varies by ART Restart and Viral Load Criteria. AIDS. 2021 Jun 14. doi: 10.1097/QAD.0000000000002978. Epub ahead of print.
PMID
34127579