Conformational variation of surface class II MHC proteins during myeloid dendritic cell differentiation accompanies structural changes in lysosomal MIIC.

Author Department

Pathology

Document Type

Article, Peer-reviewed

Publication Date

10-1-2005

Abstract

Dendritic cells (DC), uniquely among APC, express an open/empty conformation of MHC class II (MHC-II) proteins (correctly folded molecules lacking bound peptides). Generation and trafficking of empty HLA-DR during DC differentiation are investigated here.

Publication ISSN

0884-8734

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