Increased prostaglandin E2 release and activated Akt/beta-catenin signaling pathway occur after opioid withdrawal in rat spinal cord.

Author Department

Anesthesiology

Document Type

Article, Peer-reviewed

Publication Date

7-1-2006

Abstract

BACKGROUND: Prostaglandin E(2) is an important spinal modulator of nociception. However, the effects of chronic opioid administration and withdrawal on prostaglandin E(2) release and associated signaling pathways in the spinal cord are generally unknown.

Publication ISSN

0884-8734

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